ABSTRACT
Newly emerged COVID-19 performs its activity through spike protein receptor binding domain (RBD). A strong competitive binding on this site can inhibit the COVID-19 (SARS-CoV-2) activity against host cells. A significant plant bioactive molecule, Baicalein (5,6,7-Trihydroxyflavone), has noteworthy effects on viral S protein. The biomolecule was isolated from an endangered medicinal tree Oroxylum indicum L. Vent. Therapeutic use various parts of Oroxylum have been mentioned in ancient literature, Ayurveda and is also being used a folklore medicine in many tribal areas of India. Molecular docking has been applied to screen the binding pattern and bond strength of biomolecule with ten amino acids. The binding site was defined with site findder algorithm. The residues were found Arg403, Glu406, Lys417, Tyr453, Ser494, Tyr495, Gly496, Phe497, Asn501, Tyr505. The biomolecule Baicalein showed effective binding capacity towards active site residues of SARS-CoV-2 spike receptor-binding domain. It was found to have a strong binding affinity with RBD of S-protein of viral residues with high negative binding free energy (-12.5545 kcal/mol). Such competitive interruption of hydrogen bond formation between the viral S-protein and biomolecules' active sites would inhibit the potency of COVID-19 infectivity. Copyright © RJPT All right reserved.
ABSTRACT
Yoga is a holistic approach to mental and physical health and is classified by the national institutes of health as a form of complementary and alternative medicine for human life. COVID-19 pandemic has impacted the quality of life of oral health care professionals. Our aim was to assess the effect of yoga on the quality of life of these professionals. Thirty participants (12 male/18 female) with a mean age 40.5 +/- 2.5 years were prepared utilizing a 45-minute common yoga protocol module.All members went to 24 sessions over a 4-week regimen. A standard WHOQOL-BREF survey was utilized to evaluate the QOL in 4 areas (physical, psychological, social and environmental). The responses in terms of scores from the survey were investigated utilizing independent student 't' test. The change in the QOL following a 4-week yoga session was our studied outcome. After 4 weeks there was a significant change in physical domain (p=0.001), psychological domain (p=0.045) and in the total mean WHOQOL score (p=0.028).It was found that integrating yoga in daily curriculum does enhance the quality of life of oral healthcare professionals in the current COVID 19 Pandemic